Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens

Species of the family Bufonidae, better known as true toads, are widespread and produce
bioactive substances in the secretions obtained from specialized skin macroglands. Some true toads
have been employed as a folk remedy to treat infectious diseases caused by microbial pathogens.
Recent publications based on in silico analysis highlighted the Bufonidae as promising sources of
antimicrobial peptides. A review of the literature reveals that Bufonidae skin secretion extracts
show inhibitory activity in vitro against clinical isolates of bacteria, resistant and standard strains of
bacterial, and fungal and parasitic human pathogens. Secondary metabolites belonging to the classes
of alkaloids, bufadienolides, and peptides with antimicrobial activity have been isolated from species
of the genera Bufo, Bufotes, Duttaphrynus, and Rhinella. Additionally, some antimicrobial extracts and
purified compounds display low cytotoxicity against mammal cells.


Candelario Rodriguez
Roberto Ibanez
Louise A Rollins-Smith
Marcelino Gutierrez

Editorial: Estación Científica Coiba AIP
Tamaño: 2.9Mb
Soporte: Digital
Formato: Pdf (.pdf)
Idioma: Ingles